Sodium Bicarbonate → HCID 14883431, compound

HRID 1710046Notes

Reaction equation

HRID 1710046 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([NH:9][N:10]([CH3:15])[C:11]([NH:13][CH3:14])=[S:12])=O)=[CH:3][CH:2]=1.C([O-])(O)=O.[Na+]>>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:13]([CH3:14])[C:11](=[S:12])[N:10]([CH3:15])[N:9]=2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 148834304-Pyridinecarboxylic acid, 2-methyl-2-[(methylamino)thioxomethyl]hydrazide

Product 1

HCID 14883431HCID 14883431, compound

Procedure

The 1:1 mixture from Example 2 and 1 molar aqueous NaHCO3 (100 ml, 1.00×10-1 mole) were stirred and warmed to reflux. After refluxing for 15 hours the reaction was allowed to cool in an ice bath. The resulting precipitate was collected by filtration and was dried by suction. The desired product was crystallized from ethyl acetate/hexane to yield large colorless plates: 4.1 g (35%), mp 150°-152° C.

Workup

  1. temperaturewarmed to reflux
  2. temperatureAfter refluxing for 15 hours the reaction
  3. temperatureto cool in an ice bath
  4. filtrationThe resulting precipitate was collected by filtration
  5. customwas dried by suction
  6. customThe desired product was crystallized from ethyl acetate/hexane
  7. customto yield large colorless plates

Sources & evidence

ORD record
ord-db7f6b9004554351a799a41079d7f70f
Source dataset
uspto-grants-1990_08
Patent number
US04952593

Reaction notes

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