Sodium Bicarbonate → HCID 14883433, compound

HRID 1710047Notes

Reaction equation

HRID 1710047 reaction equation
[CH3:1][N:2]([C:11]([NH:13][CH3:14])=[S:12])[NH:3][C:4]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)=O.C([O-])(O)=O.[Na+]>>[CH3:1][N:2]1[C:11](=[S:12])[N:13]([CH3:14])[C:4]([C:6]2[S:7][CH:8]=[CH:9][CH:10]=2)=[N:3]1

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 14883432HCID 14883432, compound

Product 1

HCID 14883433HCID 14883433, compound

Procedure

A stirred mixture of 2,4-dimethyl-1-(2-thienoyl)thiosemicarbazide (4.7g, 2.0×10-2 mole) and 1 molar aqueous NaHCO3 (200 ml, 2.00×10-2 mole) was heated to reflux for 6 hours. The reaction mixture was then placed in the refrigerator for several hours before the precipitate was collected by filtration. Crystallization from isopropanol afforded long colorless needles: 3.6 g (83%), mp 128°-129° C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 6 hours
  3. waitThe reaction mixture was then placed in the refrigerator for several hours before the precipitate
  4. filtrationwas collected by filtration
  5. customCrystallization from isopropanol
  6. customafforded long colorless needles

Sources & evidence

ORD record
ord-f70f5a40f5784828b0f58c2ba578cd8e
Source dataset
uspto-grants-1990_08
Patent number
US04952593

Reaction notes

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