Dimethylformamide → HCID 23035470, compound

HRID 1710086Notes

Reaction equation

HRID 1710086 reaction equation
S(Cl)([Cl:3])=O.[N:5]1([CH2:11][C:12]2[CH:13]=[C:14]([CH:21]=[CH:22][CH:23]=2)[O:15][CH2:16][CH2:17][C:18](O)=[O:19])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.CN(C)C=O>ClCCl>[ClH:3].[N:5]1([CH2:11][C:12]2[CH:13]=[C:14]([CH:21]=[CH:22][CH:23]=2)[O:15][CH2:16][CH2:17][C:18]([Cl:3])=[O:19])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 154971Propanoic acid, 3-(3-(1-piperidinylmethyl)phenoxy)-

Product 1

HCID 23035470HCID 23035470, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (23.8 g) was added slowly to a cooled (0° C.) mixture of 3-[3-(piperidinomethyl)phenoxy]propionic acid and dimethylformamide (0.5 ml) in dichloromethane (100 ml). The resulting suspension was stirred at room temperature overnight, and solvent was removed under reduced pressure to give 3-[3-(piperidinomethyl)phenoxy]propionyl chloride hydrochloride (18.9 g) as an oil.

Workup

  1. temperaturea cooled
  2. customsolvent was removed under reduced pressure

Sources & evidence

ORD record
ord-bcfa00329ee74a6a9dd421b43f5b8a4c
Source dataset
uspto-grants-1990_08
Patent number
US04952589

Reaction notes

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