HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 2-[3-[3-(Pyrrolidinomethyl)phenoxy]propylamino]benzthiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 2-Chlorobenzothiazole | HCID 11987 | — |
| Reactant | 3-{3-[(Pyrrolidin-1-yl)methyl]phenoxy}propan-1-amine | HCID 12797454 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 2-[3-[3-(Pyrrolidinomethyl)phenoxy]propylamino]benzthiazole | HCID 23035469 | — |
Reaction Steps
3-[3-(Pyrrolidinomethyl)phenoxy]propylamine (2.0 g) and 2-chlorobenzthiazole (1.45 g) were fused at 130° C. for 21/2 hours. The cooled reaction mixture was subjected to column chromatography on silica using chloroform and then chloroform:methanol (10:1) as eluants to give the title compound as a yellow oil. This was treated with maleic acid in ethanol to give 2-[3-[3-(pyrrolidinomethyl)phenoxy]propylamino]benzthiazole dimaleate (0.35 g), m.p. 91°-92° C. (recrystallised from isopropanol/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952589 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-9c465d47a38c43aba73ff38ea955cf65 |
| Source note | uspto-grants-1990_08 |