5-Bromonicotinic acid → 5-(5-Chloro-2-methoxyphenyl)pyridine-3-carboxylic acid

HRID 1710328Notes

Reaction equation

HRID 1710328 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1B(O)O.C(C1C=CC(B(O)O)=CC=1)(O)=O.Br[C:26]1[CH:27]=[N:28][CH:29]=[C:30]([CH:34]=1)[C:31]([OH:33])=[O:32]>>[Cl:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[C:4]([C:26]2[CH:27]=[N:28][CH:29]=[C:30]([CH:34]=2)[C:31]([OH:33])=[O:32])[CH:5]=1

Participants

4

Reactant 3

HCID 887075-Bromonicotinic acidHCID 3121834-Carboxyphenylboronic AcidHCID 27357515-Chloro-2-methoxyphenylboronic acid

Product 1

HCID 529841285-(5-Chloro-2-methoxyphenyl)pyridine-3-carboxylic acid

Procedure

Following the procedure of Example 1b), except substituting 2-methoxy-5-chlorophenylboronic acid; for 4-carboxyphenylboronic acid; and substituting 5-bromonicotinic acid; for the compound of 1a), the title compound was prepared. MS (ES) m/z 264 [M+H].

Sources & evidence

ORD record
ord-a170e721fba843efacca68a3b168ba58
Source dataset
uspto-grants-2010_09
Patent number
US07790704B2

Reaction notes

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