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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1710328Generated: October 31, 2026

5-Bromonicotinic acid → 5-(5-Chloro-2-methoxyphenyl)pyridine-3-carboxylic acid

https://huagongshe.com/reaction/1710328

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromonicotinic acidHCID 88707—
Reactant4-Carboxyphenylboronic AcidHCID 312183—
Reactant5-Chloro-2-methoxyphenylboronic acidHCID 2735751—
Product5-(5-Chloro-2-methoxyphenyl)pyridine-3-carboxylic acidHCID 52984128—

Reaction Steps

Following the procedure of Example 1b), except substituting 2-methoxy-5-chlorophenylboronic acid; for 4-carboxyphenylboronic acid; and substituting 5-bromonicotinic acid; for the compound of 1a), the title compound was prepared. MS (ES) m/z 264 [M+H].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07790704B2
Source datasetuspto-grants-2010_09
ORD IDord-a170e721fba843efacca68a3b168ba58
Source noteuspto-grants-2010_09