N-Methylbenzylamine → 5-(Benzyl-methyl-amino)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

HRID 1710349Notes

Reaction equation

HRID 1710349 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1Cl)=[O:13])[CH2:8]2.[CH3:26][NH:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1[N:27]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:26])=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 7669N-MethylbenzylamineHCID 575502625-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide2×

Product 1

HCID 252050095-(Benzyl-methyl-amino)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

Procedure

5-(Benzyl-methyl-amino)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide was prepared using Procedure A from 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Intermediate 3) and N-methylbenzylamine. Mass spectrum (ES) MH+=441.

Sources & evidence

ORD record
ord-0a7dfb196a2342fea23deeee02b9c272
Source dataset
uspto-grants-2010_09
Patent number
US07790711B2

Reaction notes

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