HRID1710377

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1

HCID87949

p-Anisyldithiophosphonic anhydride

C14H14O2P2S4

结构：O=C1CCCCC(CCc2nc3cc(-c4ccc(S(=O)(=O)N5CCC5)cc4)cnc3[nH]2)N1

HCID178516007

未命名化合物

2 次

PRODUCTS

生成物

结构：O=S(=O)(c1ccc(-c2cnc3[nH]c(CCC4CCCCC(=S)N4)nc3c2)cc1)N1CCC1

HCID178527293

未命名化合物

收率 37.1%

PROCEDURE

实验过程

The title compound is synthesized as described for 7-[2-(6-{4-cyano-phen-1-yl}-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-azepan-2-thione (compound A2) from 258 mg of 7-(2-{6-[4-(azetidine-1-sulfonyl)-phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}-ethyl)-azepan-2-one (compound B6) and 242 mg of Lawesson's reagent. Purification by chromatography on flash silica gel (eluent gradient: dichloromethane/0-5 vol. % ethanol) affords 99 mg of the title compound as a beige foam. ESI-MS: 470.2 (MH+). TLC: Rf=0.45 (dichloromethane/ethanol 10:1 parts by volume).

WORKUP

后处理

customThe title compound is synthesized
customPurification by chromatography on flash silica gel (eluent gradient: dichloromethane/0-5 vol. % ethanol)