Lawesson's reagent → HCID 178527293, compound

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Reaction Steps

The title compound is synthesized as described for 7-[2-(6-{4-cyano-phen-1-yl}-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-azepan-2-thione (compound A2) from 258 mg of 7-(2-{6-[4-(azetidine-1-sulfonyl)-phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}-ethyl)-azepan-2-one (compound B6) and 242 mg of Lawesson's reagent. Purification by chromatography on flash silica gel (eluent gradient: dichloromethane/0-5 vol. % ethanol) affords 99 mg of the title compound as a beige foam. ESI-MS: 470.2 (MH+). TLC: Rf=0.45 (dichloromethane/ethanol 10:1 parts by volume).

Provenance & Evidence