反应详情

温度

50 °C

A 3M aqueous solution of NaOH (0.27 mL) was added to 58 mg (0.20 mmol) of 4,4-dimethyl-1-oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-7-carboxylic acid ethyl ester in 5 mL of EtOH. After 3 h an additional 0.27 mL of NaOH (3M) was added followed by 1 mL of H2O, and the mixture was heated to 50° C. for 3 h. The mixture was diluted with water, chilled to 0° C., and concentrated HCl was added until the pH reached 2. The resulting suspension was stirred for 1 h at 0° C. then filtered and washed with water. The filter was dried in the vacuum oven at 60° C. overnight to provide 51 mg of 4,4-dimethyl-1-oxo-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole-7-carboxylic acid.

1. temperaturechilled to 0° C.
2. filtrationthen filtered
3. washwashed with water
4. customThe filter was dried in the vacuum oven at 60° C. overnight