3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazine → 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyridin-2-ylthiazol-5-yl)methanone

HRID 1710469Notes

Reaction equation

HRID 1710469 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]2[CH2:17][CH2:16][CH2:15][NH:14][N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2].Cl.[CH3:19][C:20]1[N:21]=[C:22]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=2)[S:23][C:24]=1[C:25](Cl)=[O:26]>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]2[CH2:17][CH2:16][CH2:15][N:14]([C:25]([C:24]3[S:23][C:22]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=4)=[N:21][C:20]=3[CH3:19])=[O:26])[N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]

Participants

3

Reactant 2

HCID 115938543-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazineHCID 1317283174-Methyl-2-pyridin-2-ylthiazole-5-carbonyl chloride, hydrochloride

Product 1

HCID 104781841-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyridin-2-ylthiazol-5-yl)methanoneYield 78.8%

Procedure

Analogously to Example 2, reaction of 1.1 g of 3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazine with 1.2 g of 4-methyl-2-pyridin-2-ylthiazole-5-carbonyl chloride, hydrochloride (“BB”) gives the compound 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyridin-2-ylthiazol-5-yl)methanone (1.5 g).

Sources & evidence

ORD record
ord-8e8194e3927f4715858d9b82334229c5
Source dataset
uspto-grants-2010_09
Patent number
US07790723B2

Reaction notes

Loading…