HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazine → 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyridin-2-ylthiazol-5-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazine | HCID 11593854 | — |
| Reactant | 4-Methyl-2-pyridin-2-ylthiazole-5-carbonyl chloride, hydrochloride | HCID 131728317 | — |
| Product | 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyridin-2-ylthiazol-5-yl)methanone | HCID 10478184 | 78.8% |
Reaction Steps
Analogously to Example 2, reaction of 1.1 g of 3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazine with 1.2 g of 4-methyl-2-pyridin-2-ylthiazole-5-carbonyl chloride, hydrochloride (“BB”) gives the compound 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyridin-2-ylthiazol-5-yl)methanone (1.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790723B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-8e8194e3927f4715858d9b82334229c5 |
| Source note | uspto-grants-2010_09 |