Ethyl indole-2-carboxylate → Ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate

HRID 1710510ノート

反応式

HRID 1710510 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5]2.[CH2:16](OC(C1NC2C(C=1)=CC=CC=2)=O)C>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:16])[C:6]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5]2

参加物

3

反応物 2

HCID 73125Ethyl indole-2-carboxylateHCID 2727899ethyl 5-fluoro-1H-indole-2-carboxylate

生成物 1

HCID 10775338Ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate収率 100%

実験手順

According to the procedure of Preparation 1 (a), except substituting ethyl 5-fluoro-indole-2-carboxylate for the ethyl-indole-2-carboxylate, the title compound (3.3 g, 100%) was prepared as a white solid: MS (ES) m/e 222 (M+H)+.

出典と根拠

ORDレコード
ord-1f99ce686ac747708fb6ca225edd8729
出典データセット
uspto-grants-2010_09
特許番号
US07790716B2

反応ノート

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