Sodium Hydroxide → N,1-Dimethyl-5-fluoro-1H-indole-2-carboxamide
反応式
[OH-].[Na+].[F:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8]([C:14]([O:16]CC)=O)=[CH:7]2.[CH3:19][N:20]1C2C(=CC=CC=2)C=C1C(OCC)=O>>[CH3:19][NH:20][C:14]([C:8]1[N:9]([CH3:13])[C:10]2[C:6]([CH:7]=1)=[CH:5][C:4]([F:3])=[CH:12][CH:11]=2)=[O:16]参加物
4
実験手順
According to the procedure of Preparation 1 (b), except substituting ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate for the ethyl 1-methyl-1H-indole-2-carboxy late, the title compound (2.1 g, 68%) was prepared as a white solid: MS (ES) m/e 207 (M+H)+.
出典と根拠
- ORDレコード
- ord-09fb2ad2ce1e40eb8016a14d3720b066
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07790716B2
反応ノート
読み込み中…