methyl((1-methyl-1H-indol-2-yl)methyl)amine → [(5-Fluoro-1H-indol-2-yl)methyl]-methylamine

HRID 1710512Notes

Reaction equation

HRID 1710512 reaction equation
CN1C2C(=CC=CC=2)C=C1CNC.[CH3:14][NH:15][C:16]([C:18]1[N:19](C)[C:20]2[C:25]([CH:26]=1)=[CH:24][C:23]([F:27])=[CH:22][CH:21]=2)=O.CNC(C1N(C)C2C(C=1)=CC=CC=2)=O>>[F:27][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18]([CH2:16][NH:15][CH3:14])=[CH:26]2

Participants

4

Reactant 3

HCID 11401058methyl((1-methyl-1H-indol-2-yl)methyl)amineHCID 12303315N,1-dimethylindole-2-carboxamideHCID 22593743N,1-Dimethyl-5-fluoro-1H-indole-2-carboxamide

Product 1

HCID 22593726[(5-Fluoro-1H-indol-2-yl)methyl]-methylamineYield 78%

Procedure

According to the procedure of Preparation 1 (c), except substituting N,1-dimethyl-5-fluoro-1H-indole-2-carboxamide for the N,1-dimethyl-1H-indole-2-carboxamide, the title compound (1.5 g, 78%) was prepared as a white solid: MS (ES) m/e 193 (M+H)+.

Sources & evidence

ORD record
ord-e4f2f78bf0724edbad000d92af5a3517
Source dataset
uspto-grants-2010_09
Patent number
US07790716B2

Reaction notes

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