Formaldehyde → HCID 42603375, compound

HRID 1710606Notes

Reaction equation

HRID 1710606 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[C:22]3[O:21][C:20]([F:24])([F:23])[O:19][C:18]=3[CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:6][C:5]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.C=O.[C:33](O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].S([O-])([O-])(=O)=O.[Na+].[Na+]>ClCCl>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[C:22]3[O:21][C:20]([F:24])([F:23])[O:19][C:18]=3[CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:6][C:5]=1[N:25]1[CH2:30][CH2:29][N:28]([CH3:33])[CH2:27][CH2:26]1

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 24436Sodium SulfateHCID 5049666Sodium triacetoxyborohydrideHCID 67095157HCID 67095157, compound

Product 1

HCID 42603375HCID 42603375, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

285 mg of the product were obtained by reaction of 2,2-Difluoro-benzo[1,3]dioxole-4-sulfonic acid (4-methoxy-3-piperazin-1-yl-phenyl)-amide hydrochloride with formaldehyde, sodium triacetoxyborohydride and sodium sulphate in dichloromethane.

Sources & evidence

ORD record
ord-e32b57d5beca4373ad3539506bfd964f
Source dataset
uspto-grants-2010_09
Patent number
US07790727B2

Reaction notes

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