Formaldehyde → 3-Difluoromethoxy-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzenesulfonamide

HRID 1710622Notes

Reaction equation

HRID 1710622 reaction equation
Cl.[F:2][CH:3]([F:29])[O:4][C:5]1[CH:6]=[C:7]([S:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([N:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[CH:16]=2)(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1.C=O.[C:32](O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>>[F:29][CH:3]([F:2])[O:4][C:5]1[CH:6]=[C:7]([S:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([N:23]3[CH2:24][CH2:25][N:26]([CH3:32])[CH2:27][CH2:28]3)[CH:16]=2)(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 252567323-Difluoromethoxy-N-(4-methoxy-3-piperazin-1-yl-phenyl)-benzenesulfonamide Hydrochloride2×

Product 1

HCID 426028383-Difluoromethoxy-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzenesulfonamide

Procedure

The compound was prepared by reaction of 3-difluoromethoxy-N-[4-methoxy-3-(piperazin-1-yl)-phenyl]-benzenesulfonamide hydrochloride (compound of example 1) with aqueous formaldehyde and sodium triacetoxyborohydride as described for example 5.

Sources & evidence

ORD record
ord-bd9c6b9a6a5e4a1d86993bede904ce79
Source dataset
uspto-grants-2010_09
Patent number
US07790727B2

Reaction notes

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