2,2-Difluoro-2H-1,3-benzodioxole-4-sulfonyl chloride → HCID 67094937, compound

HRID 1710624Notes

Reaction equation

HRID 1710624 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:21][C:22]1([F:35])[O:26][C:25]2[CH:27]=[CH:28][CH:29]=[C:30]([S:31]([Cl:34])(=[O:33])=[O:32])[C:24]=2[O:23]1>>[ClH:34].[N:11]1([C:14]2[CH:19]=[C:18]([NH:20][S:31]([C:30]3[C:24]4[O:23][C:22]([F:35])([F:21])[O:26][C:25]=4[CH:27]=[CH:28][CH:29]=3)(=[O:32])=[O:33])[CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 177501112,2-Difluoro-2H-1,3-benzodioxole-4-sulfonyl chlorideHCID 22330182tert-Butyl 4-(3-aminophenyl)piperazine-1-carboxylate

Product 1

HCID 67094937HCID 67094937, compound

Procedure

The compound was prepared as described for Example 28 by reaction of 4-(5-aminophenyl)-piperazine-1-carboxylic acid tert-butyl ester with commercially available 2,2-Difluorobenzo[1,3]dioxole-4-sulfonyl chloride followed by deprotection under acidic conditions.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e322331f344041188dd780fd545d3220
Source dataset
uspto-grants-2010_09
Patent number
US07790727B2

Reaction notes

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