HCID 58834339, compound → HCID 16059632, compound

HRID 1710657Notes

Reaction equation

HRID 1710657 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:38]=[CH:37][C:14]2[N:15]([CH2:19][C:20]([N:22]3[CH2:27][CH2:26][N:25]([C:28]4[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([O:35][CH3:36])[CH:29]=4)[CH2:24][CH2:23]3)=[O:21])[C:16](=[O:18])[O:17][C:13]=2[CH:12]=1)(C)(C)C>Cl.O1CCOCC1>[NH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:38]=[CH:37][C:14]2[N:15]([CH2:19][C:20]([N:22]3[CH2:27][CH2:26][N:25]([C:28]4[CH:33]=[CH:32][C:31]([Cl:34])=[C:30]([O:35][CH3:36])[CH:29]=4)[CH2:24][CH2:23]3)=[O:21])[C:16](=[O:18])[O:17][C:13]=2[CH:12]=1

Participants

3

Reactant 1

HCID 58834339HCID 58834339, compound

Product 1

HCID 16059632HCID 16059632, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

[2-(3-{2-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-2-oxo-2,3-dihydro-benzooxazol-6-yloxy)-ethyl]-carbamic acid tert-butyl ester (58) (50 mg) was dissolved in HCl-dioxane (2 ml) and the resultant solution was stirred for 1 hour and concentrated to dryness. The crude residue was purified by HPLC to provide 6-(2-amino-ethoxy)-3-{2-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-3H-benzooxazol-2-one: LCMS observed for (M+H)+: 461.5.

Workup

  1. concentrationconcentrated to dryness
  2. customThe crude residue was purified by HPLC

Sources & evidence

ORD record
ord-b7b4603a025747bca9bf4d726de2ebf5
Source dataset
uspto-grants-2010_09
Patent number
US07790726B2

Reaction notes

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