4-[(4-Fluorophenyl)methyl]piperidin-4-ol → 2-Chloro-1-[4-(4-fluoro-benzyl)-4-hydroxy-piperidin-1-yl]-ethanone

HRID 1710675Notes

Reaction equation

HRID 1710675 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][C:7]2([OH:13])[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[Cl:16][CH2:17][C:18](N1CC(=O)N(C2C=CC=C(Cl)C=2C)C1)=[O:19]>>[Cl:16][CH2:17][C:18]([N:10]1[CH2:9][CH2:8][C:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:15][CH:14]=2)([OH:13])[CH2:12][CH2:11]1)=[O:19]

Participants

3

Reactant 2

HCID 104886244-[(4-Fluorophenyl)methyl]piperidin-4-olHCID 594340271-(2-Chloro-acetyl)-3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one

Product 1

HCID 588343402-Chloro-1-[4-(4-fluoro-benzyl)-4-hydroxy-piperidin-1-yl]-ethanone

Procedure

2-Chloro-1-[4-(4-fluoro-benzyl)-4-hydroxy-piperidin-1-yl]-ethanone was prepared from 4-(4-fluorobenzyl)piperidin-4-ol according to the procedure described for Compound 76 in Example 40.

Sources & evidence

ORD record
ord-e1950f22ab1d4c3e9f84acee99be3893
Source dataset
uspto-grants-2010_09
Patent number
US07790726B2

Reaction notes

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