反应详情

To a 0° C. stirred solution of 5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-amine (Example 115) (1.10 g, 4.11 mmol) in a mixture of DMSO (13 mL) and water (0.34 mL), was added N-bromosuccinimide (0.77 g, 4.32 mmol) in portions. After stirring for 5 h at room temperature, the mixture was poured into water, the precipitate collected by filtration, washed with water and dried to give the title compound as a green solid (0.44 g, 31%).

1. filtrationthe precipitate collected by filtration
2. washwashed with water
3. customdried