N-bromobutanimide → 3-Bromo-5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-amine

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Reaction Steps

To a 0° C. stirred solution of 5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-amine (Example 115) (1.10 g, 4.11 mmol) in a mixture of DMSO (13 mL) and water (0.34 mL), was added N-bromosuccinimide (0.77 g, 4.32 mmol) in portions. After stirring for 5 h at room temperature, the mixture was poured into water, the precipitate collected by filtration, washed with water and dried to give the title compound as a green solid (0.44 g, 31%).

Provenance & Evidence