HCID 59457562, compound → HCID 178522379, compound

HRID 1710722Notes

Reaction equation

HRID 1710722 reaction equation
C([O:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[N:20]=[C:19]([NH:21][C:22]([CH:24]3[CH2:26][CH2:25]3)=[O:23])[CH:18]=[N:17][C:16]=2[C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[N:20]=[C:19]([NH:21][C:22]([CH:24]3[CH2:26][CH2:25]3)=[O:23])[CH:18]=[N:17][C:16]=2[C:27]2[CH:28]=[CH:29][N:30]=[CH:31][CH:32]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 59457562HCID 59457562, compound

Product 1

HCID 178522379HCID 178522379, compoundYield 27.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a stirred solution of N-[6-(6-benzyloxypyridin-3-yl)-5-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide (0.22 g, 0.51 mmol) in ethanol (11 mL) was added palladium on activated carbon (10%) (0.033 g) and the mixture was hydrogenated under atmospheric pressure. After 18 h, the mixture was filtered, washed with ethanol and evaporated under vacuum to provide the titled compound as a brown solid (0.046 g, 27%).

Workup

  1. filtrationthe mixture was filtered
  2. washwashed with ethanol
  3. customevaporated under vacuum

Sources & evidence

ORD record
ord-fafbd0ee16b545c18e21001cab6e0314
Source dataset
uspto-grants-2010_09
Patent number
US07790728B2

Reaction notes

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