Morpholine → HCID 178505991, compound

HRID 1710730Notes

Reaction equation

HRID 1710730 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[N:9]=[C:10]2[N:22]=[C:21](S(C)(=O)=O)[NH:20][C:11]2=[N:12][C:13]=1[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1.[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[N:9]=[C:10]2[N:22]=[C:21]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[NH:20][C:11]2=[N:12][C:13]=1[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 178504838HCID 178504838, compound

Product 1

HCID 178505991HCID 178505991, compoundYield 48%

Conditions

Temperature
120 °C

Procedure

A mixture of 5-(3-fluoropyridin-4-yl)-2-(methylsulfonyl)-6-pyridin-3-yl-1H-imidazo[4,5-b]pyrazine (0.060 g, 0.16 mmol) and morpholine (1.5 mL) were heated to 120° C. in a sealed tube. After 3 hours, the mixture was evaporated and the residue was purified by silica gel chromatography eluting with dichloromethane/methanol (95:5) to give the title compound (0.029 g, 48%) as a white solid.

Workup

  1. customthe mixture was evaporated
  2. customthe residue was purified by silica gel chromatography
  3. washeluting with dichloromethane/methanol (95:5)

Sources & evidence

ORD record
ord-dad58017916e4b14bc6639909d332ed9
Source dataset
uspto-grants-2010_09
Patent number
US07790728B2

Reaction notes

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