Morpholine → HCID 178505991, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3-fluoropyridin-4-yl)-2-(methylsulfonyl)-6-pyridin-3-yl-1H-imidazo[4,5-b]pyrazine (0.060 g, 0.16 mmol) and morpholine (1.5 mL) were heated to 120° C. in a sealed tube. After 3 hours, the mixture was evaporated and the residue was purified by silica gel chromatography eluting with dichloromethane/methanol (95:5) to give the title compound (0.029 g, 48%) as a white solid.

Provenance & Evidence