HCID 68499482, compound → HCID 136046542, compound

HRID 1710769Notes

Reaction equation

HRID 1710769 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][CH:17]=[C:18]([CH2:20][N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)[N:19]=2)=[CH:11][C:10]=1[F:27])C1C=CC=CC=1>C(O)C>[F:27][C:10]1[CH:11]=[C:12]([C:15]2[O:16][CH:17]=[C:18]([CH2:20][N:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)[N:19]=2)[CH:13]=[CH:14][C:9]=1[OH:8]

Participants

3

Reactant 1

HCID 68499482HCID 68499482, compound

Product 1

HCID 136046542HCID 136046542, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-fluoro-4-(4-piperidin-1-ylmethyl-oxazol-2-yl)-phenol i68 is synthesized according to the following method: a solution of 1-({2-[4-(benzyloxy)-3-fluorophenyl]-1,3-oxazol-4-yl}methyl)piperidine i63 (0.34 g, 0.94 mmol, 1 eq) in ethanol is placed under hydrogen atmosphere (20 psi) at 30° C. for 6 hours. The mixture is filtered over cellite and concentrated under vacuo to give 0.22 g of 2-fluoro-4-(4-piperidin-1-ylmethyl-oxazol-2-yl)-phenol i68 as a brown solid. This crude product is used in the next step without any purification.

Workup

  1. custom2-fluoro-4-(4-piperidin-1-ylmethyl-oxazol-2-yl)-phenol i68 is synthesized
  2. customat 30° C.
  3. customfor 6 hours
  4. filtrationThe mixture is filtered over cellite
  5. concentrationconcentrated under vacuo

Sources & evidence

ORD record
ord-aa4060ba03d941bab3e91f86e94508b0
Source dataset
uspto-grants-2010_09
Patent number
US07790720B2

Reaction notes

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