HCID 68499482, compound → HCID 136046542, compound

Participants

Reaction Steps

2-fluoro-4-(4-piperidin-1-ylmethyl-oxazol-2-yl)-phenol i68 is synthesized according to the following method: a solution of 1-({2-[4-(benzyloxy)-3-fluorophenyl]-1,3-oxazol-4-yl}methyl)piperidine i63 (0.34 g, 0.94 mmol, 1 eq) in ethanol is placed under hydrogen atmosphere (20 psi) at 30° C. for 6 hours. The mixture is filtered over cellite and concentrated under vacuo to give 0.22 g of 2-fluoro-4-(4-piperidin-1-ylmethyl-oxazol-2-yl)-phenol i68 as a brown solid. This crude product is used in the next step without any purification.

Provenance & Evidence