反应详情

A mixture of ethyl 2-(6-chloropyridin-3-yl)-4-methyl-1,3-thiazole-5-carboxylate i97 (0.55 g, 1 eq, 1.94 mmol) and lithium hydroxide monohydrate (0.16 g, 2 eq, 3.89 mmol) in tetrahydrofurane/water (28 ml 1:0.1, v/v) is stirred at room temperature for 1 h 30. The mixture is diluted with water and extracted with ethyl acetate. The aqueous layer is then acidified to pH 2 with 2 N hydrochloric acid. The precipitate that forms is filtered and washed with water to give 0.48 g of 2-(6-chloropyridin-3-yl)-4-methyl-1,3-thiazole-5-carboxylic acid i98.

1. extractionextracted with ethyl acetate
2. filtrationThe precipitate that forms is filtered
3. washwashed with water