反应详情

温度

60 °C

A mixture of ethyl {2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}acetate i102 (0.5 g, 1.41 mmol, 1 eq) and sodium hydroxide (0.2 g, 5 mmol, 3.5 eq) in ethanol (15 ml) is stirred at 60° C. for 1 h 30. A 1 N hydrochloric acid solution (6 ml) is added and ethanol is removed under vacuum. The residue is dissolved in ethyl acetate (200 ml). The organic layer is washed with water (2×50 ml), brine, dried over magnesium sulfate, filtered and concentrated to yield 0.5 g of {2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazol-5-yl}acetic acid i103 as a white solid. This solid is used as such in the next step.

1. customethanol is removed under vacuum
2. dissolutionThe residue is dissolved in ethyl acetate (200 ml)
3. washThe organic layer is washed with water (2×50 ml), brine
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated