Methyl iodide → HCID 178488380, compound

HRID 1710817Notes

Reaction equation

HRID 1710817 reaction equation
[CH3:1][I:2].[CH3:3][O:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[NH:13][C:12](=[S:15])[NH:11][CH:10]2[CH3:16]>CC(C)=O>[IH:2].[CH3:3][O:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[N:13]=[C:12]([S:15][CH3:1])[NH:11][CH:10]2[CH3:16]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86251909HCID 86251909, compound

Product 1

HCID 178488380HCID 178488380, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Methyl iodide (1.92 g, 14 mmol) was added to a solution of 8-methoxy-4-methyl-3,4-dihydro-1H-quinazoline-2-thione (940 mg, 5 mmol) in acetone (6 ml), and the mixture was stirred for 3 h at r.t. The precipitated title compound (1.2 g, 76%) was filtered off and was used without further purification in the next step.

Workup

  1. customThe precipitated title compound (1.2 g, 76%)
  2. filtrationwas filtered off
  3. customwas used without further purification in the next step

Sources & evidence

ORD record
ord-91b7206c3ea343f3b2098f5d7b4e9c15
Source dataset
uspto-grants-2010_09
Patent number
US07790733B2

Reaction notes

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