Potassium Hydroxide → HCID 86609755, compound

HRID 1710822Notes

Reaction equation

HRID 1710822 reaction equation
[OH-].[K+].[Cl:3][C:4]1[CH:15]=[C:14]([O:16][CH3:17])[C:7]2[NH:8]C(=O)[O:10][CH:11]([CH3:12])[C:6]=2[C:5]=1[CH3:18]>CO>[NH2:8][C:7]1[C:14]([O:16][CH3:17])=[CH:15][C:4]([Cl:3])=[C:5]([CH3:18])[C:6]=1[CH:11]([OH:10])[CH3:12]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 68408095HCID 68408095, compound

Product 1

HCID 86609755HCID 86609755, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1N aqueous potassium hydroxide solution (13.5 ml, 13.5 mmol) was added to 6-chloro-8-methoxy-4,5-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one (0.66 g, 2.7 mmol) dissolved in methanol (13.5 ml). The reaction was heated 6 hours to reflux. A solid precipitated. After cooling the reaction was diluted with water, and the title compound was filtered off, washed with water and dried to yield an off-white solid (512 mg, 88%).

Workup

  1. temperatureThe reaction was heated 6 hours
  2. temperatureto reflux
  3. customA solid precipitated
  4. temperatureAfter cooling the reaction
  5. additionwas diluted with water
  6. filtrationthe title compound was filtered off
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-108c1b261fa34a30a35a70d402eb9ace
Source dataset
uspto-grants-2010_09
Patent number
US07790733B2

Reaction notes

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