Potassium Hydroxide → HCID 86609755, compound

Participants

Reaction Steps

1N aqueous potassium hydroxide solution (13.5 ml, 13.5 mmol) was added to 6-chloro-8-methoxy-4,5-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one (0.66 g, 2.7 mmol) dissolved in methanol (13.5 ml). The reaction was heated 6 hours to reflux. A solid precipitated. After cooling the reaction was diluted with water, and the title compound was filtered off, washed with water and dried to yield an off-white solid (512 mg, 88%).

Provenance & Evidence