Cyclopentylamine → HCID 131728318, compound

HRID 1710824Notes

Reaction equation

HRID 1710824 reaction equation
[CH2:1]=[C:2]([O:9][CH:10]1[CH:15]2[C:13]([N:16]3[CH:24]=[N:23][C:22]4[C:17]3=[N:18][C:19]([Cl:26])=[N:20][C:21]=4Cl)([CH2:14]2)[CH2:12][CH2:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH:27]1([NH2:32])[CH2:31][CH2:30][CH2:29][CH2:28]1>CO>[CH2:1]=[C:2]([O:9][CH:10]1[CH:15]2[C:13]([N:16]3[CH:24]=[N:23][C:22]4[C:17]3=[N:18][C:19]([Cl:26])=[N:20][C:21]=4[NH:32][CH:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)([CH2:14]2)[CH2:12][CH2:11]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 2906CyclopentylamineHCID 131728319HCID 131728319, compound

Product 1

HCID 131728318HCID 131728318, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 12 (42 mg, 0.105 mmol) in methanol (2 ml) was added cyclopentylamine at room temperature, and stirring was continued for 6 hr for complete reaction. Solvent was removed under vacuum, and the residue obtained was purified by flash column chromatography using 7/3 petroleum ether/ethylacetate as eluent to furnish 45 mg of the product 15 (90% yield) as a gum.

Workup

  1. customwas continued for 6 hr for complete reaction
  2. customSolvent was removed under vacuum
  3. customthe residue obtained
  4. customwas purified by flash column chromatography

Sources & evidence

ORD record
ord-49411e1d34e54ac8bd7899d4bc4fdf6b
Source dataset
uspto-grants-2010_09
Patent number
US07790735B2

Reaction notes

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