HRID1710951

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2756424

tert-Butyl (2-aminoethyl)methylcarbamate

C8H18N2O2

结构：CN(C)C(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1

HCID11540724

未命名化合物

PRODUCTS

生成物

结构：CN(CCNC(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1)C(=O)OC(C)(C)C

HCID59424483

未命名化合物

PROCEDURE

实验过程

Following the procedures described above for the synthesis of compound 8a (Example 1, scheme 1) but replacing dimethyl amine with tert-butyl 2-aminoethyl(methyl)carbamate, title compound 138 was obtained (13%). LRMS (M+1) 638.2 (100%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9bbe05a2c70b48b0b12b36ba19effec1
来源数据集: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07790729B2
来源说明: uspto-grants-2010_09

反应 SMILES

[CH3:1][N:2](C)[C:3]([C:5]1[S:13][C:12]2[C:7](=[N:8][CH:9]=[CH:10][C:11]=2[O:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][C:25](=[O:33])[CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[S:23])=[CH:17][C:16]=2[F:34])[CH:6]=1)=[O:4].NC[CH2:38][N:39]([CH3:47])[C:40](=[O:46])[O:41][C:42]([CH3:45])([CH3:44])[CH3:43]>>[F:34][C:16]1[CH:17]=[C:18]([NH:21][C:22]([NH:24][C:25](=[O:33])[CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[S:23])[CH:19]=[CH:20][C:15]=1[O:14][C:11]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:6]=[C:5]([C:3]([NH:2][CH2:1][CH2:38][N:39]([CH3:47])[C:40](=[O:46])[O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:4])[S:13][C:12]=12