反应详情

To a suspension of 234 (280 mg, 0.868 mmol) in THF (8 mL) was added 2-phenyl acetyl isothiocyanate (185 mg, 1.04 mmol). The reaction mixture was stirred for 3 hours, concentrated; the solid residue washed with Et2O and dried, to afford title compound 235 (229 mg, 53% yield) as a white-rose solid. 1HNMR: (DMSO-d6) δ (ppm): 12.41 (s, 1H), 11.75 (s, 1H), 8.54(d, J=5.3 Hz, 1H), 7.98 (s, 1H), 7.96(d, J=13.5 Hz, 1H), 7.48(d, J=5.0 Hz, 2H), 7.30-7.26(m, 2H), 7.26-7.18 (m, 3H), 6.69(d, J=5.5 Hz, 1H), 3.25 (s, 2H), 2.98 (s, 3H). MS (m/z): 500.1 (M+1).

1. concentrationconcentrated
2. washthe solid residue washed with Et2O
3. customdried