Dichloromethane → N-((1-((6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)acetamide

HRID 171102Notes

Reaction equation

HRID 171102 reaction equation
[CH3:33][C:34]([Cl:35])=[O:36].[CH:24]([N:25]([CH2:26][CH3:27])[CH:28]([CH3:29])[CH3:30])([CH3:31])[CH3:32].[Cl:37][CH2:38][Cl:39].[NH2:1][CH2:2][c:3]1[c:4]([C:20]([F:21])([F:22])[F:23])[n:5][n:6]([CH2:8][c:9]2[nH:10][c:11](=[O:19])[c:12]3[c:13]([n:14]2)[s:15][c:16]([CH3:18])[cH:17]3)[cH:7]1>>[NH:1]([CH2:2][c:3]1[c:4]([C:20]([F:21])([F:22])[F:23])[n:5][n:6]([CH2:8][c:9]2[nH:10][c:11](=[O:19])[c:12]3[c:13]([n:14]2)[s:15][c:16]([CH3:18])[cH:17]3)[cH:7]1)[C:34]([CH3:33])=[O:36]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 665917222-((4-(aminomethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one

Product 1

HCID 66591725N-((1-((6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)acetamide

Sources & evidence

ORD record
ord-1cd629072812420085db6add79b4c961
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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