4-Methylpyrazole → N-(4-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

HRID 1711032Notes

Reaction equation

HRID 1711032 reaction equation
CC1C=NN([C:7]2[S:15][C:14]3[C:9](=[N:10][CH:11]=[CH:12][C:13]=3[O:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([NH:26][C:27](=[O:35])[CH2:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)=[S:25])=[CH:19][CH:18]=3)[CH:8]=2)C=1.CC1C=NNC=1.[CH3:42][C:43]1[CH:47]=[C:46]([CH3:48])[NH:45][N:44]=1>>[CH3:42][C:43]1[CH:47]=[C:46]([CH3:48])[N:45]([C:7]2[S:15][C:14]3[C:9](=[N:10][CH:11]=[CH:12][C:13]=3[O:16][C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:24]([NH:26][C:27](=[O:35])[CH2:28][C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)=[S:25])=[CH:21][CH:22]=3)[CH:8]=2)[N:44]=1

Participants

4

Reactant 3

HCID 34064-MethylpyrazoleHCID 62103,5-DimethylpyrazoleHCID 86604190N-(4-(2-(4-Methyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Product 1

HCID 86604192N-(4-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Procedure

Following the procedures described above for the synthesis of compound 258a (example 215, scheme 58) but replacing 4-methyl-1H-pyrazole in the step 1 with 3,5-dimethyl-1H-pyrazole, title compound 258c was obtained. Characterization of 258c is provided in the table 23.

Sources & evidence

ORD record
ord-d5e5e068420145ccb0f5247afc271293
Source dataset
uspto-grants-2010_09
Patent number
US07790729B2

Reaction notes

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