反应详情

温度

90 °C

To a solution of 281 (288 mg, 0.94 mmol) in AcOH (25 mL) at 90° C., was added iron powder (238 mg, 4.25 mmol), and the reaction mixture was stirred vigorously at 90° C. for 10 min, cooled, filtered through a Celite pad and concentrated. The residue was purified by flash column chromatography (eluent EtOAc) to afford the title compound 282 (248 mg, 95%) as an off-white solid. MS (m/z): 308.1 (M+H) (found).

1. temperaturecooled
2. filtrationfiltered through a Celite pad
3. concentrationconcentrated
4. customThe residue was purified by flash column chromatography (eluent EtOAc)