反应详情

Using general procedure E with 3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butylamine (4.50 g, 21.0 mmol) and 4,6-dimethyl-pyrimidine-5-carboxylic acid (3.20 g, 21.0 mmol), followed by purification by column chromatography on silica gel (2-10% MeOH/CH2Cl2) gave 4,6-dimethyl-pyrimidine-5-carboxylic acid [3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butyl]-amide (5.10 g, 73%).

1. customfollowed by purification by column chromatography on silica gel (2-10% MeOH/CH2Cl2)