HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dimethylpyrimidine-5-carboxylic acid → HCID 86629513, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dimethylpyrimidine-5-carboxylic acid | HCID 14922222 | — |
| Reactant | 3-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-butylamine | HCID 68775101 | — |
| Product | HCID 86629513 | HCID 86629513 | 73% |
Reaction Steps
Using general procedure E with 3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butylamine (4.50 g, 21.0 mmol) and 4,6-dimethyl-pyrimidine-5-carboxylic acid (3.20 g, 21.0 mmol), followed by purification by column chromatography on silica gel (2-10% MeOH/CH2Cl2) gave 4,6-dimethyl-pyrimidine-5-carboxylic acid [3-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-butyl]-amide (5.10 g, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790747B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-54851c9deba04fa4a1dd88b37390e727 |
| Source note | uspto-grants-2010_09 |