3-Methylbenzylamine → HCID 22643530, compound

HRID 1711141Notes

Reaction equation

HRID 1711141 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].[C:10]([N:17]1[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]1)([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]>>[C:13]([O:12][C:10]([N:17]1[CH2:22][CH2:21][CH:20]([NH:6][CH2:5][C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([CH3:1])[CH:3]=2)[CH2:19][CH2:18]1)=[O:11])([CH3:16])([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 660153-MethylbenzylamineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22643530HCID 22643530, compoundYield 82%

Procedure

Using general procedure A, 3-methylbenzylamine (198 μL, 1.58 mmol) and 1-Boc-4-piperidone (300 mg, 1.51 mmol) afforded 4-(3-methylbenzylamino)-piperidine-1-carboxylic acid tert-butyl ester as a white solid (375 mg, 82%).

Sources & evidence

ORD record
ord-41e1704cf51141598d138171fd9677f3
Source dataset
uspto-grants-2010_09
Patent number
US07790747B2

Reaction notes

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