Tetrahydropyran-4-ylacetic acid → HCID 68776849, compound

HRID 1711142Notes

Reaction equation

HRID 1711142 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:23]1[CH2:28][CH2:27][CH:26]([CH2:29][C:30](O)=[O:31])[CH2:25][CH2:24]1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=2)[C:30](=[O:31])[CH2:29][CH:26]2[CH2:27][CH2:28][O:23][CH2:24][CH2:25]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2773575Tetrahydropyran-4-ylacetic acidHCID 22643530HCID 22643530, compound

Product 1

HCID 68776849HCID 68776849, compoundYield 42%

Procedure

Using general procedure E, 4-(3-methylbenzylamino)-piperidine-1-carboxylic acid tert-butyl ester (365 mg, 1.2 mmol) and (tetrahydropyran-4-yl)-acetic acid (173 mg, 1.2 mmol) afforded 4-[(3-methylbenzyl)-(2-tetrahydropyran-4-yl-acetyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester as a white solid (217 mg, 42%).

Sources & evidence

ORD record
ord-875a8c7fdcb54f049ddb10704c2a72ab
Source dataset
uspto-grants-2010_09
Patent number
US07790747B2

Reaction notes

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