Tetrahydropyran-4-ylacetic acid → HCID 68776849, compound

Participants

Reaction Steps

Using general procedure E, 4-(3-methylbenzylamino)-piperidine-1-carboxylic acid tert-butyl ester (365 mg, 1.2 mmol) and (tetrahydropyran-4-yl)-acetic acid (173 mg, 1.2 mmol) afforded 4-[(3-methylbenzyl)-(2-tetrahydropyran-4-yl-acetyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester as a white solid (217 mg, 42%).

Provenance & Evidence