HRID1711199

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3446563

6-Chloro-2,4-dimethylnicotinic acid

C8H8ClNO2

结构：COC[C@@H]1CN(Cc2ccc(C(=O)OC)cc2)C(=O)N1C1CCN(C(C)CCN)CC1

HCID68777023

未命名化合物

PRODUCTS

生成物

结构：COC[C@@H]1CN(Cc2ccc(C(=O)OC)cc2)C(=O)N1C1CCN(C(C)CCNC(=O)c2c(C)cc(Cl)nc2C)CC1

HCID86629537

未命名化合物

收率 60%

PROCEDURE

实验过程

According to general procedure E, 4-{(S)-3-[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-4-methoxymethyl-2-oxo-imidazolidin-1-ylmethyl}-benzoic acid methyl ester (40 mg) and 6-chloro-2,4-dimethyl-nicotinic acid gave 4-[(S)-3-(1-{3-[(6-chloro-2,4-dimethyl-pyridine-3-carbonyl)-amino]-1-methyl-propyl}-piperidin-4-yl)-4-methoxymethyl-2-oxo-imidazolidin-1-ylmethyl]-benzoic acid methyl ester (32 mg, 60%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d9b8f55b3d3f4566acd2745b444a8f99
来源数据集: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07790747B2
来源说明: uspto-grants-2010_09

反应 SMILES

[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:15][C@@H:14]([CH2:16][O:17][CH3:18])[N:13]([CH:19]3[CH2:24][CH2:23][N:22]([CH:25]([CH3:29])[CH2:26][CH2:27][NH2:28])[CH2:21][CH2:20]3)[C:12]2=[O:30])=[CH:6][CH:5]=1.[Cl:32][C:33]1[CH:41]=[C:40]([CH3:42])[C:36]([C:37](O)=[O:38])=[C:35]([CH3:43])[N:34]=1>>[CH3:1][O:2][C:3](=[O:31])[C:4]1[CH:5]=[CH:6][C:7]([CH2:10][N:11]2[CH2:15][C@@H:14]([CH2:16][O:17][CH3:18])[N:13]([CH:19]3[CH2:24][CH2:23][N:22]([CH:25]([CH3:29])[CH2:26][CH2:27][NH:28][C:37]([C:36]4[C:35]([CH3:43])=[N:34][C:33]([Cl:32])=[CH:41][C:40]=4[CH3:42])=[O:38])[CH2:21][CH2:20]3)[C:12]2=[O:30])=[CH:8][CH:9]=1