HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-2,4-dimethylnicotinic acid → 4-[(S)-3-(1-{3-[(6-chloro-2,4-dimethyl-pyridine-3-carbonyl)-amino]-1-methyl-propyl}-piperidin-4-yl)-4-methoxymethyl-2-oxo-imidazolidin-1-ylmethyl]-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-2,4-dimethylnicotinic acid | HCID 3446563 | — |
| Reactant | 4-{(S)-3-[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-4-methoxymethyl-2-oxo-imidazolidin-1-ylmethyl}-benzoic acid methyl ester | HCID 68777023 | — |
| Product | 4-[(S)-3-(1-{3-[(6-chloro-2,4-dimethyl-pyridine-3-carbonyl)-amino]-1-methyl-propyl}-piperidin-4-yl)-4-methoxymethyl-2-oxo-imidazolidin-1-ylmethyl]-benzoic acid methyl ester | HCID 86629537 | 60% |
Reaction Steps
According to general procedure E, 4-{(S)-3-[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-4-methoxymethyl-2-oxo-imidazolidin-1-ylmethyl}-benzoic acid methyl ester (40 mg) and 6-chloro-2,4-dimethyl-nicotinic acid gave 4-[(S)-3-(1-{3-[(6-chloro-2,4-dimethyl-pyridine-3-carbonyl)-amino]-1-methyl-propyl}-piperidin-4-yl)-4-methoxymethyl-2-oxo-imidazolidin-1-ylmethyl]-benzoic acid methyl ester (32 mg, 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790747B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-d9b8f55b3d3f4566acd2745b444a8f99 |
| Source note | uspto-grants-2010_09 |