Ammonium Chloride → HCID 69775286, compound

HRID 1711204Notes

Reaction equation

HRID 1711204 reaction equation
[CH3:1][C:2]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]([CH3:19])[C:3]=1[CH2:4][S:5][CH:6]1[CH2:12][CH2:11][CH2:10][NH:9][C:8](=O)[CH2:7]1.[NH4+].[Cl-]>C1COCC1>[CH3:1][C:2]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]([CH3:19])[C:3]=1[CH2:4][S:5][CH:6]1[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 69794577HCID 69794577, compound

Product 1

HCID 69775286HCID 69775286, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.3 g of 4-(R/S)-(2,4,6-trimethyl-benzyl-sulfanyl)-azepan-2-one are added to a mixture of 15 ml of a 1M-solution of LiAlH3 and 50 ml THF are added. The mixture obtained is heated for 1 hour at 80°, poured into 200 ml of a 20% aqueous NH4Cl-solution and the mixture obtained is extracted with EtAc. The organic phase obtained is dried and solvent is evaporated. 4-(R/S)-(2,4,6-Trimethyl-benzyl-sulfanyl)-azepane is obtained.

Workup

  1. additionare added
  2. customThe mixture obtained
  3. temperatureis heated for 1 hour at 80°
  4. customthe mixture obtained
  5. extractionis extracted with EtAc
  6. customThe organic phase obtained
  7. customis dried
  8. customsolvent is evaporated

Sources & evidence

ORD record
ord-c24ece572ae245c68893cc4fce9eca2f
Source dataset
uspto-grants-2010_09
Patent number
US07790749B2

Reaction notes

Loading…