Diisopropylethylamine → HCID 178504235, compound

HRID 1711319Notes

Reaction equation

HRID 1711319 reaction equation
[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[N:17]([Sn](C)(C)C)[N:16]=[N:15][N:14]=3)[CH:10]=[CH:9][C:8]=2[NH2:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.[K+].[C:24]([C:26]1[N:27]=[C:28]([C:39]([O-])=[O:40])[N:29]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:30]=1)#[N:25].C1CN([P+](Br)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>>[C:1]1([C:7]2[CH:12]=[C:11]([C:13]3[NH:17][N:16]=[N:15][N:14]=3)[CH:10]=[CH:9][C:8]=2[NH:22][C:39]([C:28]2[N:29]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:30]=[C:26]([C:24]#[N:25])[N:27]=2)=[O:40])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 2733179PyBroPHCID 58754854HCID 58754854, compoundHCID 67188357potassium 4-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

Product 1

HCID 178504235HCID 178504235, compound

Procedure

The title compound was prepared from 2-cyclohex-1-enyl-4-(1-trimethylstannanyl-1H-tetrazol-5-yl)-phenylamine (as prepared in the previous step), potassium 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylate (as prepared in Example 11, step (d)), PyBroP and DIEA according to the procedure in Example 11, step (f). Mass spectrum (ESI, m/z): Calcd. for C24H30N8O2Si, 491.2, found 491.1.

Sources & evidence

ORD record
ord-4bdb02bee8714b3980246aebaf979ce8
Source dataset
uspto-grants-2010_09
Patent number
US07790724B2

Reaction notes

Loading…