HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylethylenediamine → HCID 16065814, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 68500278 | HCID 68500278 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16065814 | HCID 16065814 | — |
Reaction Steps
A solution of [6-chloro-3-(3-methyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]decane-8-carbonyl)-indol-1-yl]-acetic acid in DMF was treated sequentially with 1 eq. of O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 1 eq. of N,N-diisopropylethylamine and 1 eq. of N,N-dimethylethylenediamine. The mixture was shaken at room temperature for 12 h, concentrated and purified by prep. HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790752B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-46bffbb62fd0477db5ce2706546352e6 |
| Source note | uspto-grants-2010_09 |