Dichloromethane → [3,4-Dimethoxy-5-(1-triisopropylsilanyloxyethyl)phenyl][4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino]acetonitrile

HRID 171152Notes

Reaction equation

HRID 171152 reaction equation
[CH3:14][O:15][c:16]1[cH:17][c:18]([CH:19]=[O:20])[cH:21][c:22]([CH:26]([CH3:27])[O:28][Si:29]([CH:30]([CH3:31])[CH3:32])([CH:33]([CH3:34])[CH3:35])[CH:36]([CH3:37])[CH3:38])[c:23]1[O:24][CH3:25].[CH3:1][c:2]1[n:3][c:4](-[c:7]2[cH:8][cH:9][c:10]([NH2:13])[cH:11][cH:12]2)[n:5][o:6]1.[CH3:39][Si:40]([CH3:41])([CH3:42])[C:43]#[N:44].[Cl:45][CH2:46][Cl:47]>>[CH3:1][c:2]1[n:3][c:4](-[c:7]2[cH:8][cH:9][c:10]([NH:13][CH:19]([c:18]3[cH:17][c:16]([O:15][CH3:14])[c:23]([O:24][CH3:25])[c:22]([CH:26]([CH3:27])[O:28][Si:29]([CH:30]([CH3:31])[CH3:32])([CH:33]([CH3:34])[CH3:35])[CH:36]([CH3:37])[CH3:38])[cH:21]3)[C:43]#[N:44])[cH:11][cH:12]2)[n:5][o:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 82115Trimethylsilyl cyanideHCID 181881764-(5-Methyl-1,2,4-oxadiazol-3-yl)anilineHCID 595171933,4-Dimethoxy-5-(1-triisopropylsilanyloxyethyl)benzaldehyde

Product 1

HCID 67097068[3,4-Dimethoxy-5-(1-triisopropylsilanyloxyethyl)phenyl][4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylamino]acetonitrile

Sources & evidence

ORD record
ord-4e2a6ab72f504c3f9aed3b8f9f01fce9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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