反应详情

温度

0 °C

To a solution of LiAlH4 (699 mg, 18.4 mmol) in THF (15 mL) was added tert-butyl 4-(4-amino-3-fluorophenoxy)picolinate (1.4 g, 4.6 mmol) at 0° C. under N2. The mixture was stirred at 0° C. for 2 h. The reaction mixture was quenched with 10% aq NaOH solution (4 mL), the resultant suspension was filtered and the filtrate was extracted with EtOAc (3×30 mL) to give (4-(4-amino-3-fluorophenoxy)pyridin-2-yl)methanol (700 mg, 70% yield). MS (ESI) m/z: 235.1 (M+H+).

1. customThe reaction mixture was quenched with 10% aq NaOH solution (4 mL)
2. filtrationthe resultant suspension was filtered
3. extractionthe filtrate was extracted with EtOAc (3×30 mL)